| UniProtKB AC (Name) | UniProtKB Section | Organism | Description | |
|---|---|---|---|---|
| A0AVF1 (IFT56_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Intraflagellar transport protein 56; Tetratricopeptide repeat protein 26; | |
| O95201 (RHIT_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Transcriptional repressor RHIT; Repressor of heat-inducible transcription; Zinc finger protein 205; Zinc finger protein 210; | |
| A8MQ27 (NEU1B_HUMAN) | Swiss-Prot | Homo sapiens (Human) | E3 ubiquitin-protein ligase NEURL1B; Neuralized-2; Neuralized-like protein 1B; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL1B; | |
| Q6P9H4 (CNKR3_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Connector enhancer of kinase suppressor of ras 3; CNK homolog protein 3; CNKSR family member 3; Maguin-like protein; | |
| Q96K49 (TM87B_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Transmembrane protein 87B; | |
| A6NK97 (S22AK_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Solute carrier family 22 member 20; Organic anion transporter 6; Solute carrier family 22 member 20 pseudogene; | |
| Q7Z6M2 (FBX33_HUMAN) | Swiss-Prot | Homo sapiens (Human) | F-box only protein 33; | |
| Q9N2J8 (ENH3_HUMAN) | Swiss-Prot | Homo sapiens (Human) | HERV-H_2q24.1 provirus ancestral Env polyprotein; Env protein HERV-H/p59; Envelope polyprotein; HERV-H/env59; Surface protein; SU; Transmembrane protein; TM; | |
| Q9Y625 (GPC6_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Glypican-6; Secreted glypican-6; | |
| Q6GPH6 (IPIL1_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; | |
| Q68EA5 (ZNF57_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Zinc finger protein 57; Zinc finger protein 424; | |
| Q2M329 (CCD96_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Coiled-coil domain-containing protein 96; | |
| P14222 (PERF_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Perforin-1; Cytolysin; Lymphocyte pore-forming protein; | |
| Q8NB59 (SYT14_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Synaptotagmin-14; Synaptotagmin XIV; | |
| Q3SY00 (T10IP_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Testis-specific protein 10-interacting protein; Tsga10-interacting protein; | |
| Q9BW71 (HIRP3_HUMAN) | Swiss-Prot | Homo sapiens (Human) | HIRA-interacting protein 3; | |
| Q8IUC8 (GLT13_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Polypeptide N-acetylgalactosaminyltransferase 13; Polypeptide GalNAc transferase 13; Protein-UDP acetylgalactosaminyltransferase 13; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13; | |
| Q63HN1 (S31F2_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Putative protein SPATA31F2P; Putative protein FAM205B; | |
| O75487 (GPC4_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Glypican-4; K-glypican; Secreted glypican-4; | |
| A6NKX4 (S22AV_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Putative solute carrier family 22 member 31; | |
| O75564 (JERKY_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Jerky protein homolog; | |
| Q8N976 (YG039_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Putative uncharacterized protein FLJ38264; | |
| Q69YW2 (STUM_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Protein stum homolog; | |
| Q8N5N4 (CC022_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Uncharacterized protein C3orf22; | |
| Q5MJ09 (SPXN3_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Sperm protein associated with the nucleus on the X chromosome N3; Nuclear-associated protein SPAN-Xn3; SPANX family member N3; | |
| Q96PE5 (OPALI_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Opalin; Oligodendrocytic myelin paranodal and inner loop protein; Transmembrane protein 10; | |
| Q9NWH2 (TM242_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Transmembrane protein 242; | |
| Q06055 (AT5G2_HUMAN) | Swiss-Prot | Homo sapiens (Human) | ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 2; ATP synthase proteolipid P2; ATP synthase proton-transporting mitochondrial F(0) complex subunit C2; ATPase protein 9; ATPase subunit c; | |
| Q13901 (C1D_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Nuclear nucleic acid-binding protein C1D; | |
| Q8N7U9 (CQ054_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Putative uncharacterized protein encoded by LINC00469; | |
| O75379 (VAMP4_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Vesicle-associated membrane protein 4; | |
| Q9Y5J1 (UTP18_HUMAN) | Swiss-Prot | Homo sapiens (Human) | U3 small nucleolar RNA-associated protein 18 homolog; WD repeat-containing protein 50; | |
| Q9H4I0 (RD21L_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Double-strand-break repair protein rad21-like protein 1; | |
| Q32NB8 (PGPS1_HUMAN) | Swiss-Prot | Homo sapiens (Human) | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; Phosphatidylglycerophosphate synthase 1; | |
| Q9UL16 (CFA45_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Cilia- and flagella-associated protein 45; Coiled-coil domain-containing protein 19; Nasopharyngeal epithelium-specific protein 1; | |
| Q9Y226 (S22AD_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Solute carrier family 22 member 13; Organic anion transporter 10; Organic cation transporter-like 3; | |
| Q96S66 (CLCC1_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Chloride channel CLIC-like protein 1; Mid-1-related chloride channel protein 1; | |
| O95199 (RCBT2_HUMAN) | Swiss-Prot | Homo sapiens (Human) | RCC1 and BTB domain-containing protein 2; Chromosome condensation 1-like; RCC1-like G exchanging factor; Regulator of chromosome condensation and BTB domain-containing protein 2; | |
| Q9NP74 (PALMD_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Palmdelphin; Paralemmin-like protein; | |
| Q8IYJ2 (CJ067_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Uncharacterized protein C10orf67, mitochondrial; | |
| Q96C11 (FGGY_HUMAN) | Swiss-Prot | Homo sapiens (Human) | FGGY carbohydrate kinase domain-containing protein; D-ribulokinase FGGY; | |
| Q9BZR9 (TRIM8_HUMAN) | Swiss-Prot | Homo sapiens (Human) | E3 ubiquitin-protein ligase TRIM8; Glioblastoma-expressed RING finger protein; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; Tripartite motif-containing protein 8; | |
| O95678 (K2C75_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Keratin, type II cytoskeletal 75; Cytokeratin-75; Keratin-6 hair follicle; Keratin-75; Type II keratin-K6hf; Type-II keratin Kb18; | |
| Q9NQ89 (CL004_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Protein C12orf4; | |
| Q8N4F4 (S22AO_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Steroid transmembrane transporter SLC22A24; Solute carrier family 22 member 24; | |
| O60291 (MGRN1_HUMAN) | Swiss-Prot | Homo sapiens (Human) | E3 ubiquitin-protein ligase MGRN1; Mahogunin RING finger protein 1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; | |
| Q9NUV7 (SPTC3_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Serine palmitoyltransferase 3; Long chain base biosynthesis protein 2b; Long chain base biosynthesis protein 3; Serine-palmitoyl-CoA transferase 3; | |
| Q494X3 (ZN404_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Zinc finger protein 404; | |
| P15586 (GNS_HUMAN) | Swiss-Prot | Homo sapiens (Human) | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; | |
| Q6UY01 (LRC31_HUMAN) | Swiss-Prot | Homo sapiens (Human) | Leucine-rich repeat-containing protein 31; |
Homo sapiens (Latin: "wise man") is the species name for humans. Believed to have originated in Africa, Homo sapiens is the only surviving member of the Homo genus.
The first complete draft of the human genome was completed in 2001 with an estimated cost of $300million. With the advances in DNA sequencing methods, this price has dropped dramatically down to almost $1000 per genome. By combining the individual genome information with other data, such as protein structure models, personalised medicine becomes viable.
From left to right: i) The number of proteins in the reference proteome of Homo sapiens, ii) the number of unique protein sequences for which at least one model is available, iii) the total number of models and iv) a coverage bar plot is shown.
The bar plot shows the coverage for every protein in the reference proteome of Homo sapiens for which there is at least one model. Different colours (dark green to red boxes) represent the coverage of the targets. Targets with high coverage are represented in dark green (more than 80% of the target's length is covered by models), whereas low coverage is shown in red. The size of each box is proportional to the number of target sequences with a given coverage.
For information on the latest proteome for Homo sapiens, please visit Proteome.
You can easily download the latest protein sequences for Homo sapiens proteome here. Please note this download is for the current UniProtKB release, which may be different to release 2024_02 that was used for the most up to date SWISS-MODEL Repository.
| Proteins in proteome | Sequences modelled | Models |
| 20,598 | 17,358 | 42,928 |
Detailed coverage numbers are obtained by hovering the mouse over one of the boxes.
The plot shows the evolution over years (x-axis) of the fraction of Homo sapiens reference proteome residues (y-axis) for which structural information is available. Different colors (light blue to dark blue) in the plot represent the quality of the sequence alignment between the reference proteome sequences (targets) and the sequences of the proteins in the structure database (templates). Alignments with low sequence identity are displayed in light blue, whereas alignments with high sequence identity are depicted in dark blue. The SWISS-MODEL Template Library is used as database of templates. Only target-template alignments found by HHblits and only residues with atom coordinates are considered.
This chart shows the percentage of residues in the Homo sapiens proteome which are covered by experimental structures and the enhancement of coverage by homology modelling by the SWISS-MODEL pipeline. Experimental residue coverage is determined using SIFTS mapping. For residues which are not covered by experimental structures (including where there are no atom records in SIFTS mapping) the model coverage bars are coloured by QMEANDisCo local quality score.
Many proteins form oligomeric structures either by self-assembly (homo-oligomeric) or by assembly with other proteins (hetero-oligomeric) to accomplish their function. In SWISS-MODEL Repository, the quaternary structure annotation of the template is used to model the target sequence in its oligomeric form. Currently our method is limited to the modelling of homo-oligomeric assemblies. The oligomeric state of the template is only considered if the interface is conserved.
| Single Chain | 2-mer | 3-mer | 4-mer | 5-mer | 6-mer | 7-mer | 8-mer | 9-mer | 10-mer | 11-mer | 12-mer | 13-mer | 14-mer | 16-mer | 18-mer | 20-mer | 21-mer | 22-mer | 24-mer | 25-mer | 26-mer | 32-mer | 34-mer | 36-mer | 39-mer | 40-mer | 44-mer | 46-mer | 48-mer | 55-mer | 56-mer | 60-mer | 62-mer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 38,419 | 3,200 | 302 | 594 | 64 | 118 | 14 | 57 | 3 | 29 | 11 | 38 | 1 | 3 | 22 | 4 | 2 | 1 | 1 | 16 | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 1 | 4 | 2 | 4 | 4 | 2 |